| ncRNA name | HMGA2 siRNA |
| ncRNA Category | siRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RB cell lines Y79, WERI-RB1; RB samples |
| Methods | siRNA transfection, microarray, qRT-PCR, Western blot, flow cytometry, MTT assay |
| Expression pattern | associated |
| Functional description | HMGA2 gene silencing in cultured RB cells results in reduced cell proliferation and transition in the G1/S phase. The whole genome microarray analysis of HMGA2 silenced Y79 cells revealed overall upregulation of 1,132 genes (≥ 1.0 fold) and downregulation of 1,562 genes (≤ -1.0 fold). |
| PubMed ID | 23077401 |
| Year | 2012 |
| Title | Molecular deregulation induced by silencing of the high mobility group protein A2 gene in retinoblastoma cells. |
| Drug-related ncRNA | NO |
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